The Expert Working Group has prepared several Discussion Documents detailing recommendations that support progress towards FIT standardisation and optimisation of this technology in CRC population-based screening. Each document has been circulated for comment amongst EWG members. New documents will be posted here as they are published.
- No. 1 – FIT Standardisation
This document summarises the EWG’s recommendations on standardising FIT nomenclature, analytical information (e.g. sample stability, faecal mass, buffer volume, quality control) and units of reporting.
- No. 2 – FIT Reporting units
The mass of faeces collected and the volume and characteristics of the buffer used in the sampling device differ among different FIT making comparisons of analytical and clinical test performance difficult. This document proposes a method to standardise reporting units.
- No. 3 – Stability of haemoglobin
FIT confer the opportunity for analytical specificity for human Hb but carry vulnerability due to globin’s susceptibility to degradation, both in the colon and in the test device. This document proposes guidelines to facilitate a standardised approach to assessing and reporting the stability of faecal Hb in FIT devices.
- No. 4 – Internal Quality Control (IQC) and External Quality Assessment (EQA)
This document provides recommendations that will ensure acceptable international analytical performance in CRC screening, enable screening programmes to provide evidence that analysis is of adequate quality and enable and encourage publications that describe the use of FIT to include standardised information about analytical performance and quality.
- No. 5 – A Standard for Faecal Immunochemical TesTs for Haemoglobin Evaluation Reporting (FITTER)
Adequate descriptions of pre-analytical aspects of FIT analyses (e.g. specimen collection, handling and storage prior to analysis) and the analytical performance attained, are very often deficient or missing from published FIT research. This document describes a new standard for adequate reporting.
- No. 6 – Quantitative FIT procurement
This document proposes in detail a recommended FIT procurement process, essential for any country or organisation planning to use FIT in an organised screening programme. This is a provisional document that will be subject to revision.